There has been a lot of controversy regarding these drugs and that has made many dermatologists cautious about prescribing isotretinoin (Accutane).

关于这些药物存在很多的争论，这导致了很多皮肤科医生开异维甲酸(青春痘特效药)的处方时非常小心。

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It's known that retinoids can damage the developing fetal nervous system, which is why Accutane cannot be given to pregnant women.

众所周知类视黄醇嫩能够损伤正在发育的胎儿的神经系统，因此孕妇不能使用。

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Based on evidence from previous research, they note, Accutane might alter the regulation of brain chemicals like dopamine and serotonin, which are implicated in depression.

基于以前研究所得到的证据，他们提到，Accutane可能改变人脑中对化学物质如多巴胺和5 -羟色胺的调节，这可能与抑郁症有关。

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Roche, for its part, is facing generic competition on Accutane, one of its best-selling acne drugs.

FORBES: Roche And Schering's Desperate Duel

Utah resident Kamie Kendall began taking the anti-acne drug Accutane in 1997, as a 13-year-old.

FORBES: Three Thousand Words Of Warnings Not Enough

After her grandmother called her parents about the TV ad, Kendall testified, she thought about suing Accutane manufacturer Roche Holdings.

FORBES: Three Thousand Words Of Warnings Not Enough